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PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity


A specific population of macrophages that express high levels of the enzyme PLA2G2D in tumour-draining lymph nodes is associated with poor prognosis in patients, and inhibiting PLA2G2D improves anti-tumour immunity in mouse models.

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anti-tumour immunity

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tumour

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draining lymph nodes

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