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Osteoclasts intercept meningeal lymphatic paths for dural metastasis


Osteoclast-derived angiopoietin-2 in the dura mater impairs lymphatic vessel function and weakens anti-tumour immunity against dural metastases, which offers new therapeutic approaches to restore meningeal lymphatic function through selective osteoclast targeting.

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Photo of dural metastasis

dural metastasis

Photo of Osteoclasts

Osteoclasts