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Nobel Prize Winner Shimon Sakaguchi Reflects on How He Discovered Regulatory T Cells

Nobel laureate Shimon Sakaguchi reflects on the role of regulatory T cells in peripheral immune tolerance and how the cells could transform treatment for cancer, autoimmune disease and organ transplant rejection

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Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi won the 2025 Nobel Prize in Medicine for discovering how the body prevents autoimmune diseases through “peripheral immune tolerance.” Sakaguchi identified regulatory T cells in 1995, while Brunkow and Ramsdell later linked them to the Foxp3 gene.

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