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New technique maps genetic variants driving neurodegenerative disease risk: Instead of analyzing genetic effects by grouping cells into specific categories and determining genetic effects for each type individually, the team modeled the effects shared among seven different brain cell types.

Researchers from Penn State College of Medicine developed a new method that better maps genetic variants that can lead to brain diseases. The approach identified 75% more relevant genes and uncovered new therapeutic targets for conditions like Alzheimer’s and ALS.

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