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Finding immune cells that stop a body from attacking itself wins medicine Nobel

Shimon Sakaguchi discovered T-reg immune cells. Mary Brunkow and Fred Ramsdell identified the cells’ role in autoimmune disease.

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2025 Nobel Prize in Physiology or Medicine Awarded for Discoveries Key to Treating Autoimmune Disease

Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi won the 2025 Nobel Prize in Medicine for discovering how the body prevents autoimmune diseases through “peripheral immune tolerance.” Sakaguchi identified regulatory T cells in 1995, while Brunkow and Ramsdell later linked them to the Foxp3 gene.

Nobel prize for medicine goes to trio for work on immune tolerance

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