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A biased allosteric modulator is a molecular glue for β<sub>2</sub>AR dimerization


AP-7-168, an optimized derivative of a β-arrestin-biased negative allosteric modulator of the β2-adrenergic receptor (β2AR), functions as a molecular glue to stabilize β2AR homodimerization.

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Photo of sub>2</sub

sub>2</sub

Photo of Molecular glue

Molecular glue

Photo of AR dimerization

AR dimerization

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